In the last decades, much research has been conducted on bovine viral diarrhoea (BVD), a disease which causes a variety of clinical signs as well as deaths, abortions and huge economic losses in the cattle industry worldwide. Despite the efforts to control BVD on farms, the virus has continued to spread and is still a concern for farmers and veterinary practitioners. This guide will provide readers with essential, practical and updated knowledge to understand and fight the disease regardless of the farm’s production system. This guide has been written by Francisco J. González Rodríguez, an experienced beef and dairy cattle consultant with a special interest in bovine viral diseases and cattle management.